La disfunzione mitocondriale determina la PANoptosi mediata da ZBP1 per aumentare la suscettibilità di insufficienza cardiaca con eiezione preservata associata a fibrillazione atriale.

INTRODUCTION: Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), but underlying molecular mechanisms remain poorly defined. Mitochondrial dysfunction drives ZBP1-mediated PANoptosis is crucial in understanding the progression of HFpEF-associated AF and exploring novel therapeutic avenues. OBJECTIVES: This study investigates the Z-DNA binding protein 1 (ZBP1) as a critical mediator linking mitochondrial dysfunction with PANoptosis by sensing mitochondrial Z-DNA (mtZ-DNA) in HFpEF-associated AF. METHODS: Variety of in vivo and in vitro experimental approaches were employed, majorly including HFpEF mouse model establishment, Histologi