Analisi bayesiana di finerenone nella insufficienza cardiaca con eiezione ridotta e preservata: un'analisi pre-specificata di FINEARTS-HF.

AIMS: The non-steroidal mineralocorticoid receptor agonist (MRA) finerenone reduced heart failure events and cardiovascular death in patients with heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) in a frequentist analysis of the FINEARTS-HF trial. We applied Bayesian methods including prior information to provide probabilistic estimates of efficacy and safety. The aim of this study was to estimate the probability of different magnitudes of treatment benefit with finerenone vs. placebo using Bayesian analysis of FINEARTS-HF. METHODS AND RESULTS: In this pre-specified Bayesian analysis, we estimated treatment efficacy incorporating prior information in a robust